Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma
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چکیده
منابع مشابه
Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma
TERT is the catalytic subunit of telomerase which plays an essential part in cellular immortality by maintaining telomere integrity. TERT is commonly over-expressed in human malignancies, indicating its key role in cell transformation. The chromosome 5p15.33 TERT-CLPTM1L region has been associated with susceptibility of multiple cancers via a genome-wide association approach. However, the invol...
متن کاملThe identification of two regulatory ESCC susceptibility genetic variants in the TERT-CLPTM1L loci
The chromosome 5p15.33 TERT-CLPTM1L region has been identified by genome-wide association studies as a susceptibility locus of multiple malignancies. However, the involvement of this locus in esophageal squamous cell carcinoma (ESCC) development is still largely unclear. We fine-mapped the TERT-CLPTM1L region through genotyping 15 haplotype-tagging single nucleotide polymorphisms (htSNPs) using...
متن کاملaxin۲ is associated with papillary thyroid carcinoma
objectives the aim of this study was to explore the association between axin2 gene polymorphism and papillary thyroid carcinoma (ptc). patients and methods 106 blood samples (56 ptc patients and 50 healthy controls) were drawn from china-japan :union: hospital in jilin province, china, during october 2010 to march 2011. a case-control study was designed to examine the association between axin2 ...
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concomitant papillary thyroid cancer and parathyroid adenoma is rare. we report a 55 years old female with papillary cancer admitted for surgery. preoperative laboratory findings revealed hypercalcemia and then primary hyperparathyroidism. thyroidectomy, neck dissection and excision of parathyroid adenoma were performed. histological examination revealed parathyroid adenoma. serum calcium retur...
متن کاملThyroid Hemiagenesis Associated with Papillary Thyroid Carcinoma
Copyright c 2016, the Korean Thyroid Association. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Thyroid Hemiagenesi...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep26037